Good overview Jake. I’d add a note on the mechanism since it’s genuinely interesting: Semaglutide acts on GLP-1 receptors in the hypothalamus (satiety signaling) and also slows gastric emptying, both effects contribute to appetite regulation. The combination of central and peripheral mechanisms is part of why the appetite effects in research are more pronounced than with some earlier GLP-1 analogs.

The 7-day half-life also means once-weekly administration in clinical protocols, which is a convenience advantage worth noting.